《英文msh詞典》Eaton Lambert Syndrome
[入口詞] Eaton Lambert Syndrome
[主題詞] Lambert-Eaton Myasthenic Syndrome
[英文釋義] An autoimmune disease characterized by weakness and fatigability of proximal muscles,particularly of the pelvic girdle,lower extremities,trunk,and shoulder girdle. There is relative sparing of extraocular and bulbar muscles. CARCINOMA,SMALL CELL of the lung is a frequently associated condition,although other malignancies and autoimmune diseases may be associated. Muscular weakness results from impaired impulse transmission at the NEUROMUSCULAR JUNCTION. Presynaptic calcium channel dysfunction leads to a reduced amount of acetylcholine being released in response to stimulation of the nerve. (From Adams et al.,Principles of Neurology,6th ed,pp 1471)